About Kelch-like protein 15
Kelch-like protein 15 (KLHL15) is a protein
from Homo sapiens identified by UniProt accession
Q96M94, 604 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Kelch-like protein 15 |
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| UniProt accession | Q96M94 |
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| Gene | KLHL15 |
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| Organism | Homo sapiens |
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| Length | 604 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.49
- Abnormal brain morphology · score 0.27
- Intellectual disability · score 0.24
- benign prostatic hyperplasia · score 0.02
- cancer · score 0.01
- X-linked intellectual disability · score 0.01
- colorectal cancer · score 0.01
- acute quadriplegic myopathy · score 0.00
- pancreatic ductal adenocarcinoma · score 0.00
- metastatic melanoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M94-F1 | alphafold | PREDICTED | 91.16 | — |
Amino-acid sequence (604 residues)
MAGDVEGFCS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC CSFLLAKICL ENCAEIMRLL DDFGVNIEGV REKLDTFLLD NFVPLMSRPD FLSYLSFEKL MSYLDNDHLS RFPEIELYEA VQSWLRHDRR RWRHTDTIIQ NIRFCLMTPT SVFEKVKTSE FYRYSRQLRY EVDQALNYFQ NVHQQPLLDM KSSRIRSAKP QTTVFRGMIG HSMVNSKILL LKKPRVWWEL EGPQVPLRPD CLAIVNNFVF LLGGEELGPD GEFHASSKVF RYDPRQNSWL QMADMSVPRS EFAVGVIGKF IYAVAGRTRD ETFYSTERYD ITNDKWEFVD PYPVNKYGHE GTVLNNKLFI TGGITSSSTS KQVCVFDPSK EGTIEQRTRR TQVVTNCWEN KSKMNYARCF HKMISYNGKL YVFGGVCVIL RASFESQGCP STEVYNPETD QWTILASMPI GRSGHGVTVL DKQIMVLGGL CYNGHYSDSI LTFDPDENKW KEDEYPRMPC KLDGLQVCNL HFPDYVLDEV RRCN
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