Coiled-coil domain-containing protein 42 (CCDC42)

About Coiled-coil domain-containing protein 42

Coiled-coil domain-containing protein 42 (CCDC42) is a protein from Homo sapiens identified by UniProt accession Q96M95, 316 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 42
UniProt accession	Q96M95
Gene	CCDC42
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.08
congenital bilateral absence of vas deferens · score 0.07
spermatogenic failures 50 · score 0.06
spermatogenic failure 20 · score 0.06
spermatogenic failure 25 · score 0.06
isochromosomy Yp · score 0.06
spermatogenic failure 72 · score 0.06
spinocerebellar ataxia type 32 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96M95-F1	alphafold	PREDICTED	87.21	—

Amino-acid sequence (316 residues)

MSLGIMEEED LAEYFRLQYG ERLLQMLQKL PNVEGASESP SIWLLEKKKE TEIMHQTMVQ KKKMFQRRME TLNLRWEELG VKEAQLKAHI QKSEQFIQEN DQKRIRAMKK ANKERELKCQ HMQELTKRKQ EMVALRLEHQ RLSAKLKDYY IFNKYLEKVV ENSEFEEIHE VIARYKTLVS MRHDLMQSAQ EGQEKIERAK ARLARYMEEK DDEILQQNNE LARLQMRFDR ARSNVIFWES RWAHIQNTAA KKTLLLGTIK MATLNLFQIV SKHLKEVTEV ALEDTHKQLD MIQQFIQDRS DIWAEVKKKE QQRVRI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards