About FYVE, RhoGEF and PH domain-containing protein 4
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4) is a protein
from Homo sapiens identified by UniProt accession
Q96M96, 766 residues long.
MolForge cross-references it against 0 known binders and
123 disease associations.
Target properties
| Protein name | FYVE, RhoGEF and PH domain-containing protein 4 |
|---|
| UniProt accession | Q96M96 |
|---|
| Gene | FGD4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 766 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (123)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease type 4H · score 0.72
- Charcot-Marie-Tooth disease type 4 · score 0.55
- mean platelet volume · score 0.45
- Charcot-Marie-Tooth disease · score 0.42
- genetic disorder · score 0.41
- monocyte count · score 0.41
- hypertension · score 0.39
- reticulocyte count · score 0.36
- lymphocyte count · score 0.36
- reticulocyte measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M96-F1 | alphafold | PREDICTED | 69.87 | — |
Amino-acid sequence (766 residues)
MEEIKPASAS CVSKEKPSKV SDLISRFEGG SSLSNYSDLK KESAVNLNAP RTPGRHGLTT TPQQKLLSQH LPQRQGNDTD KTQGAQTCVA NGVMAAQNQM ECEEEKAATL SSDTSIQASE PLLDTHIVNG ERDETATAPA SPTTDSCDGN ASDSSYRTPG IGPVLPLEER GAETETKVQE RENGESPLEL EQLDQHHEMK ETNEQKLHKI ANELLLTERA YVNRLDLLDQ VFYCKLLEEA NRGSFPAEMV NKIFSNISSI NAFHSKFLLP ELEKRMQEWE TTPRIGDILQ KLAPFLKMYG EYVKGFDNAM ELVKNMTERI PQFKSVVEEI QKQKICGSLT LQHHMLEPVQ RIPRYEMLLK DYLRKLPPDS LDWNDAKKSL EIISTAASHS NSAIRKMENL KKLLEIYEML GEEEDIVNPS NELIKEGQIL KLAARNTSAQ ERYLFLFNNM LLYCVPKFSL VGSKFTVRTR VGIDGMKIVE TQNEEYPHTF QVSGKERTLE LQASSAQDKE EWIKALQETI DAFHQRHETF RNAIAKDNDI HSEVSTAELG KRAPRWIRDN EVTMCMKCKE PFNALTRRRH HCRACGYVVC WKCSDYKAQL EYDGGKLSKV CKDCYQIISG FTDSEEKKRK GILEIESAEV SGNSVVCSFL QYMEKSKPWQ KAWCVIPKQD PLVLYMYGAP QDVRAQATIP LLGYVVDEMP RSADLPHSFK LTQSKSVHSF AADSEELKQK WLKVILLAVT GETPGGPNEH PATLDDHPEP KKKSEC
Explore FYVE, RhoGEF and PH domain-containing protein 4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets