Parkin coregulated gene protein (PACRG)

About Parkin coregulated gene protein

Parkin coregulated gene protein (PACRG) is a protein from Homo sapiens identified by UniProt accession Q96M98, 296 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.

Target properties

Protein name	Parkin coregulated gene protein
UniProt accession	Q96M98
Gene	PACRG
Organism	Homo sapiens
Length	296 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (172)

Diseases linked to this target (Open Targets).

Young adult-onset Parkinsonism · score 0.43
insomnia measurement · score 0.33
hair colour measurement · score 0.30
body mass index · score 0.28
cognitive function measurement · score 0.27
young-onset Parkinson disease · score 0.27
physical activity measurement · score 0.24
smoking behavior · score 0.23
self reported educational attainment · score 0.23
adolescent idiopathic scoliosis · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96M98-F1	alphafold	PREDICTED	76.44	—

Amino-acid sequence (296 residues)

MVAEKETLSL NKCPDKMPKR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN SVVRGPPAAG AFKERPTKPT AFRKFYERGD FPIALEHDSK GNKIAWKVEI EKLDYHHYLP LFFDGLCEMT FPYEFFARQG IHDMLEHGGN KILPVLPQLI IPIKNALNLR NRQVICVTLK VLQHLVVSAE MVGKALVPYY RQILPVLNIF KNMNGSYSLP RLECSGAIMA RCNLDHLGSS DPPTSASQVA EIIVNSGDGI DYSQQKRENI GDLIQETLEA FERYGGENAF INIKYVVPTY ESCLLN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards