bMERB domain-containing protein 1 (BMERB1)

About bMERB domain-containing protein 1

bMERB domain-containing protein 1 (BMERB1) is a protein from Homo sapiens identified by UniProt accession Q96MC5, 204 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	bMERB domain-containing protein 1
UniProt accession	Q96MC5
Gene	BMERB1
Organism	Homo sapiens
Length	204 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

Testicular Germ Cell Tumor · score 0.30
neurofibrillary tangles measurement · score 0.19
platelet component distribution width · score 0.09
triglyceride measurement · score 0.08
high density lipoprotein cholesterol measurement · score 0.07
sex hormone-binding globulin measurement · score 0.07
reticulocyte measurement · score 0.06
uterine fibroid · score 0.05
familial thoracic aortic aneurysm and aortic dissection · score 0.04
congenital lipoid adrenal hyperplasia due to STAR deficency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96MC5-F1	alphafold	PREDICTED	72.87	—

Amino-acid sequence (204 residues)

MELKQSLSTH LEAEKPLRRY GAVEETAWKT ERLGRNQLDI ISMAETTMMP EEIELEMAKI QRLREVLVRR ESELRFMMDD IQLCKDIMDL KQELQNLVAI PEKEKTKLQK QREDELIQKI HKLVQKRDFL VDDAEVERLR EQEEDKEMAD FLRIKLKPLD KVTKSPASSR AEKKAEPPPS KPTVAKTGLA LIKDCCGATQ CNIM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards