About F-box/LRR-repeat protein 18
F-box/LRR-repeat protein 18 (FBXL18) is a protein
from Homo sapiens identified by UniProt accession
Q96ME1, 718 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | F-box/LRR-repeat protein 18 |
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| UniProt accession | Q96ME1 |
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| Gene | FBXL18 |
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| Organism | Homo sapiens |
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| Length | 718 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (85)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.41
- body mass index · score 0.40
- reticulocyte measurement · score 0.37
- reticulocyte count · score 0.37
- mathematical ability · score 0.36
- lymphocyte:monocyte ratio · score 0.32
- neurodegenerative disease · score 0.32
- monocyte count · score 0.29
- ankylosing spondylitis · score 0.27
- mean corpuscular hemoglobin concentration · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96ME1-F1 | alphafold | PREDICTED | 86.89 | — |
Amino-acid sequence (718 residues)
MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL NVRRTCRKLA ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS MAGCYWLPGS TVEHVARCRS LVKVNLSGCH LTSLRLSKML SALQHLRSLA IDVSPGFDAS QLSSECKATL SRVRELKQTL FTPSYGVVPC CTSLEKLLLY FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG YINQEVVRLY LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL SGCVHCLSPD SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG LGRHLCQLLA RLRHLRSLSL PVCSVADSAP RADRAPAQPA MHAVPRGFGK KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK NLPFLEHLEL IGSNFSSAMP RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ LPSVLTGSGL VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT GESLATCKSL QQSLLRSFQA ERPALNVVIF PLLHEGLTDV IRDVPLVHLD EITLFKSRVA EEPPNLWW
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