SH3 and cysteine-rich domain-containing protein 3…

About SH3 and cysteine-rich domain-containing protein 3

SH3 and cysteine-rich domain-containing protein 3 (STAC3) is a protein from Homo sapiens identified by UniProt accession Q96MF2, 364 residues long. MolForge cross-references it against 0 known binders and 244 disease associations.

Target properties

Protein name	SH3 and cysteine-rich domain-containing protein 3
UniProt accession	Q96MF2
Gene	STAC3
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (244)

Diseases linked to this target (Open Targets).

Bailey-Bloch congenital myopathy · score 0.78
Native American myopathy · score 0.72
genetic disorder · score 0.41
congenital myopathy · score 0.27
reticulocyte count · score 0.10
IGF-1 measurement · score 0.08
low density lipoprotein cholesterol measurement · score 0.07
body mass index · score 0.07
urate measurement · score 0.07
creatinine measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96MF2-F1	alphafold	PREDICTED	69.28	—

Amino-acid sequence (364 residues)

MTEKEVLESP KPSFPAETRQ SGLQRLKQLL RKGSTGTKEM ELPPEPQANG EAVGAGGGPI YYIYEEEEEE EEEEEEPPPE PPKLVNDKPH KFKDHFFKKP KFCDVCARMI VLNNKFGLRC KNCKTNIHEH CQSYVEMQRC FGKIPPGFHR AYSSPLYSNQ QYACVKDLSA ANRNDPVFET LRTGVIMANK ERKKGQADKK NPVAAMMEEE PESARPEEGK PQDGNPEGDK KAEKKTPDDK HKQPGFQQSH YFVALYRFKA LEKDDLDFPP GEKITVIDDS NEEWWRGKIG EKVGFFPPNF IIRVRAGERV HRVTRSFVGN REIGQITLKK DQIVVQKGDE AGGYVKVYTG RKVGLFPTDF LEEI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

SH3 and cysteine-rich domain-containing protein 3 (STAC3)