About E3 SUMO-protein ligase NSE2
E3 SUMO-protein ligase NSE2 (NSMCE2) is a protein
from Homo sapiens identified by UniProt accession
Q96MF7, 247 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | E3 SUMO-protein ligase NSE2 |
|---|
| UniProt accession | Q96MF7 |
|---|
| Gene | NSMCE2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 247 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (89)
Diseases linked to this target (Open Targets).
- Seckel syndrome · score 0.46
- microcephalic primordial dwarfism-insulin resistance syndrome · score 0.37
- neurodegenerative disease · score 0.35
- eosinophil count · score 0.32
- eosinophil percentage of leukocytes · score 0.25
- ovarian cancer · score 0.23
- Red cell distribution width · score 0.23
- breast adenocarcinoma · score 0.23
- monocyte count · score 0.16
- platelet count · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96MF7-F1 | alphafold | PREDICTED | 81.66 | — |
Amino-acid sequence (247 residues)
MPGRSSSNSG STGFISFSGV ESALSSLKNF QACINSGMDT ASSVALDLVE SQTEVSSEYS MDKAMVEFAT LDRQLNHYVK AVQSTINHVK EERPEKIPDL KLLVEKKFLA LQSKNSDADF QNNEKFVQFK QQLKELKKQC GLQADREADG TEGVDEDIIV TQSQTNFTCP ITKEEMKKPV KNKVCGHTYE EDAIVRMIES RQKRKKKAYC PQIGCSHTDI RKSDLIQDEA LRRAIENHNK KRHRHSE
Explore E3 SUMO-protein ligase NSE2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets