Junctional sarcoplasmic reticulum protein 1 (JSRP1)

About Junctional sarcoplasmic reticulum protein 1

Junctional sarcoplasmic reticulum protein 1 (JSRP1) is a protein from Homo sapiens identified by UniProt accession Q96MG2, 331 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Junctional sarcoplasmic reticulum protein 1
UniProt accession	Q96MG2
Gene	JSRP1
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

myeloid white cell count · score 0.21
drug use measurement · score 0.04
facioscapulohumeral muscular dystrophy 4, digenic · score 0.04
Barrett's esophagus · score 0.03
leukocyte count · score 0.03
Crohn's disease · score 0.02
esophageal adenocarcinoma · score 0.02
ulcerative colitis · score 0.01
Obesity · score 0.01
systemic scleroderma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96MG2-F1	alphafold	PREDICTED	52.75	—

Amino-acid sequence (331 residues)

MSMTTRAWEE LDGGLGSCQA LEDHSALAET QEDRASATPR LADSGSVPHD SQVAEGPSVD TRPKKMEKEP AARGTPGTGK ERLKAGASPR SVPARKKAQT APPLQPPPPP PALSEELPWG DLSLNKCLVL ASLVALLGSA FQLCRDAVPG EAALQARVPE PWVPPSSAPR EPSSPLPKFE AQAPPSAPPA PRAEAEVRPK IPGSREAAEN DEEEPGEATG EAVREDRVTL ADRGPKERPR REGKPRKEKP RKEERPKKER PRKEERPRAA REPREALPQR WESREGGHRP WARDSRDAEP RKKQAWVSPR RPDEEQRPGS RQKLRAGKGR D

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards