About DGAT1/2-independent enzyme synthesizing storage lipids
DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) is a protein
from Homo sapiens identified by UniProt accession
Q96MH6, 324 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | DGAT1/2-independent enzyme synthesizing storage lipids |
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| UniProt accession | Q96MH6 |
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| Gene | TMEM68 |
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| Organism | Homo sapiens |
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| Length | 324 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- pathological myopia · score 0.19
- taxonomic microbiome measurement · score 0.16
- gut microbiome measurement · score 0.16
- sphingomyelin measurement · score 0.12
- platelet component distribution width · score 0.10
- lymphocyte count · score 0.08
- mean platelet volume · score 0.05
- self reported educational attainment · score 0.05
- thyroid stimulating hormone measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96MH6-F1 | alphafold | PREDICTED | 88.04 | — |
Amino-acid sequence (324 residues)
MIDKNQTCGV GQDSVPYMIC LIHILEEWFG VEQLEDYLNF ANYLLWVFTP LILLILPYFT IFLLYLTIIF LHIYKRKNVL KEAYSHNLWD GARKTVATLW DGHAAVWHGY EVHGMEKIPE DGPALIIFYH GAIPIDFYYF MAKIFIHKGR TCRVVADHFV FKIPGFSLLL DVFCALHGPR EKCVEILRSG HLLAISPGGV REALISDETY NIVWGHRRGF AQVAIDAKVP IIPMFTQNIR EGFRSLGGTR LFRWLYEKFR YPFAPMYGGF PVKLRTYLGD PIPYDPQITA EELAEKTKNA VQALIDKHQR IPGNIMSALL ERFH
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