About Protein phosphatase 1M
Protein phosphatase 1M (PPM1M) is a protein
from Homo sapiens identified by UniProt accession
Q96MI6, 459 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Protein phosphatase 1M |
|---|
| UniProt accession | Q96MI6 |
|---|
| Gene | PPM1M |
|---|
| Organism | Homo sapiens |
|---|
| Length | 459 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.10
- platelet count · score 0.09
- bipolar disorder · score 0.09
- cancer · score 0.07
- neoplasm · score 0.07
- schizophrenia · score 0.07
- BMI-adjusted waist circumference · score 0.07
- glomerular filtration rate · score 0.07
- creatinine measurement · score 0.07
- total blood protein measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96MI6-F1 | alphafold | PREDICTED | 85.91 | — |
Amino-acid sequence (459 residues)
MSAGWFRRRF LPGEPLPAPR PPGPHASPVP YRRPRFLRGS SSSPGAADAS RRPDSRPVRS PARGRTLPWN AGYAEIINAE KSEFNEDQAA CGKLCIRRCE FGAEEEWLTL CPEEFLTGHY WALFDGHGGP AAAILAANTL HSCLRRQLEA VVEGLVATQP PMHLNGRCIC PSDPQFVEEK GIRAEDLVIG ALESAFQECD EVIGRELEAS GQMGGCTALV AVSLQGKLYM ANAGDSRAIL VRRDEIRPLS FEFTPETERQ RIQQLAFVYP ELLAGEFTRL EFPRRLKGDD LGQKVLFRDH HMSGWSYKRV EKSDLKYPLI HGQGRQARLL GTLAVSRGLG DHQLRVLDTN IQLKPFLLSV PQVTVLDVDQ LELQEDDVVV MATDGLWDVL SNEQVAWLVR SFLPGNQEDP HRFSKLAQML IHSTQGKEDS LTEEGQVSYD DVSVFVIPLH SQGQESSDH
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