Pseudokinase FAM20A (FAM20A)

About Pseudokinase FAM20A

Pseudokinase FAM20A (FAM20A) is a protein from Homo sapiens identified by UniProt accession Q96MK3, 541 residues long. MolForge cross-references it against 0 known binders and 294 disease associations.

Target properties

Protein name	Pseudokinase FAM20A
UniProt accession	Q96MK3
Gene	FAM20A
Organism	Homo sapiens
Length	541 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (294)

Diseases linked to this target (Open Targets).

amelogenesis imperfecta type 1G · score 0.80
heel bone mineral density · score 0.36
blood phosphate measurement · score 0.31
otosclerosis · score 0.31
body height · score 0.30
sitting height measurement · score 0.26
phosphorus measurement · score 0.25
genetic disorder · score 0.19
platelet count · score 0.12
Hypomaturation amelogenesis imperfecta · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96MK3-F1	alphafold	PREDICTED	85.24	—

Amino-acid sequence (541 residues)

MPGLRRDRLL TLLLLGALLS ADLYFHLWPQ VQRQLRPRER PRGCPCTGRA SSLARDSAAA ASDPGTIVHN FSRTEPRTEP AGGSHSGSSS KLQALFAHPL YNVPEEPPLL GAEDSLLASQ EALRYYRRKV ARWNRRHKMY REQMNLTSLD PPLQLRLEAS WVQFHLGINR HGLYSRSSPV VSKLLQDMRH FPTISADYSQ DEKALLGACD CTQIVKPSGV HLKLVLRFSD FGKAMFKPMR QQRDEETPVD FFYFIDFQRH NAEIAAFHLD RILDFRRVPP TVGRIVNVTK EILEVTKNEI LQSVFFVSPA SNVCFFAKCP YMCKTEYAVC GNPHLLEGSL SAFLPSLNLA PRLSVPNPWI RSYTLAGKEE WEVNPLYCDT VKQIYPYNNS QRLLNVIDMA IFDFLIGNMD RHHYEMFTKF GDDGFLIHLD NARGFGRHSH DEISILSPLS QCCMIKKKTL LHLQLLAQAD YRLSDVMRES LLEDQLSPVL TEPHLLALDR RLQTILRTVE GCIVAHGQQS VIVDGPVEQL APDSGQANLT S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards