About Heat shock 70 kDa protein 12B
Heat shock 70 kDa protein 12B (HSPA12B) is a protein
from Homo sapiens identified by UniProt accession
Q96MM6, 686 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Heat shock 70 kDa protein 12B |
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| UniProt accession | Q96MM6 |
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| Gene | HSPA12B |
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| Organism | Homo sapiens |
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| Length | 686 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- breast adenocarcinoma · score 0.18
- Sepsis · score 0.10
- serum gamma-glutamyl transferase measurement · score 0.09
- Neoplasm of the lung · score 0.08
- non-Hodgkins lymphoma · score 0.07
- Stroke · score 0.07
- myocardial infarction · score 0.05
- PHF-tau measurement · score 0.05
- platelet component distribution width · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96MM6-F1 | alphafold | PREDICTED | 82.41 | — |
Amino-acid sequence (686 residues)
MLAVPEMGLQ GLYIGSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE VRAPQQASFS VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH QKTPTCLLLT PEGAFHSFGY TARDYYHDLD PEEARDWLYF EKFKMKIHSA TDLTLKTQLE AVNGKTMPAL EVFAHALRFF REHALQELRE QSPSLPEKDT VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS RENAEQLLIA LEPEAASVYC RKLRLHQLLD LSGRAPGGGR LGERRSIDSS FRQAREQLRR SRHSRTFLVE SGVGELWAEM QAGDRYVVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP YGAVGVDLAF EQLLCRIFGE DFIATFKRQR PAAWVDLTIA FEARKRTAGP HRAGALNISL PFSFIDFYRK QRGHNVETAL RRSSVNFVKW SSQGMLRMSC EAMNELFQPT VSGIIQHIEA LLARPEVQGV KLLFLVGGFA ESAVLQHAVQ AALGARGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP LTYGVGVLNR FVPGRHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPADCG QDTAGAPPGR REIRAAMQFG DTEIKVTAVD VSTNRSVRAS IDFLSN
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