About Heparan-sulfate 6-O-sulfotransferase 2
Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2) is a protein
from Homo sapiens identified by UniProt accession
Q96MM7, 605 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Heparan-sulfate 6-O-sulfotransferase 2 |
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| UniProt accession | Q96MM7 |
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| Gene | HS6ST2 |
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| Organism | Homo sapiens |
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| Length | 605 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (100)
Diseases linked to this target (Open Targets).
- Paganini-Miozzo syndrome · score 0.56
- neurodegenerative disease · score 0.33
- cancer · score 0.08
- clear cell renal carcinoma · score 0.07
- neoplasm · score 0.05
- lung adenocarcinoma · score 0.05
- pancreatic adenocarcinoma · score 0.04
- alkaline phosphatase measurement · score 0.04
- non-small cell lung carcinoma · score 0.04
- bladder transitional cell carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96MM7-F1 | alphafold | PREDICTED | 73.32 | — |
Amino-acid sequence (605 residues)
MALPACAVRE FEPPRQPERG APVRTTCPRR HSRVEAELAA SRPGSVAASV RAGPPRGVSH GFHTRPLLDK PRKASSSLAG AACAPLFALL SRGRRRRMHV LRRRWDLGSL CRALLTRGLA ALGHSLKHVL GAIFSKIFGP MASVGNMDEK SNKLLLALVM LFLFAVIVLQ YVCPGTECQL LRLQAFSSPV PDPYRSEDES SARFVPRYNF TRGDLLRKVD FDIKGDDLIV FLHIQKTGGT TFGRHLVRNI QLEQPCECRV GQKKCTCHRP GKRETWLFSR FSTGWSCGLH ADWTELTSCV PSVVDGKRDA RLRPSRNFHY ITILRDPVSR YLSEWRHVQR GATWKASLHV CDGRPPTSEE LPSCYTGDDW SGCPLKEFMD CPYNLANNRQ VRMLSDLTLV GCYNLSVMPE KQRNKVLLES AKSNLKHMAF FGLTEFQRKT QYLFEKTFNM NFISPFTQYN TTRASSVEIN EEIQKRIEGL NFLDMELYSY AKDLFLQRYQ FMRQKEHQEA RRKRQEQRKF LKGRLLQTHF QSQGQGQSQN PNQNQSQNPN PNANQNLTQN LMQNLTQSLS QKENRESPKQ NSGKEQNDNT SNGTNDYIGS VEKWR
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