Zinc finger protein 488 (ZNF488)

About Zinc finger protein 488

Zinc finger protein 488 (ZNF488) is a protein from Homo sapiens identified by UniProt accession Q96MN9, 340 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Zinc finger protein 488
UniProt accession	Q96MN9
Gene	ZNF488
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
systolic blood pressure · score 0.19
pachyonychia congenita · score 0.08
neuronal ceroid lipofuscinosis 1 · score 0.04
familial isolated congenital asplenia · score 0.04
Crohn's disease · score 0.03
refractive error measurement · score 0.03
pancreatic carcinoma · score 0.03
cancer · score 0.03
neoplasm · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96MN9-F1	alphafold	PREDICTED	55.76	—

Amino-acid sequence (340 residues)

MPEWPPCLSV APALVITMAA GKGAPLSPSA ENRWRLSEPE LGRGCKPVLL EKTNRLGPEA AVGRAGRDVG SAELALLVAP GKPRPGKPLP PKTRGEQRQS AFTELPRMKD RQVDAQAQER EHDDPTGQPG APQLTQNIPR GPAGSKVFSV WPSGARSEQR SAFSKPTKRP AERPELTSVF PAGESADALG ELSGLLNTTD LACWGRLSTP KLLVGDLWNL QALPQNAPLC STFLGAPTLW LEHTQAQVPP PSSSSTTSWA LLPPTLTSLG LSTQNWCAKC NLSFRLTSDL VFHMRSHHKK EHAGPDPHSQ KRREEALACP VCQEHFRERH HLSRHMTSHS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards