About Cilia- and flagella-associated protein 44
Cilia- and flagella-associated protein 44 (CFAP44) is a protein
from Homo sapiens identified by UniProt accession
Q96MT7, 1854 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 44 |
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| UniProt accession | Q96MT7 |
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| Gene | CFAP44 |
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| Organism | Homo sapiens |
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| Length | 1854 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (121)
Diseases linked to this target (Open Targets).
- spermatogenic failure 20 · score 0.63
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- type 2 diabetes mellitus · score 0.26
- colorectal cancer · score 0.20
- colorectal adenoma · score 0.20
- cortical thickness · score 0.19
- prostate carcinoma · score 0.19
- genetic disorder · score 0.19
- sleep measurement · score 0.15
- BMI-adjusted waist-hip ratio · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96MT7-F1 | alphafold | PREDICTED | 74.60 | — |
Amino-acid sequence (1854 residues)
MKEPDDQDTD GEKSVTSKSD GKKSLRSSKS ESRSPVQEDN TFLEDDTDET FTKGEGSYLE EDSDEERLEG SLSSFQYGDL QSTTVPQQTP APAVEEAEEE VKKKISESFF YDYMELASMP FVTLDSNIPL DLLTLVHSFG YDCRKRANLQ LLDDSIAIYI AGNQLIFLNL KTKEQIYLRS SSGEGIGVIG VHPHKTYFTV AEKGSFPDII IYEYPSLRPY RVLRDGTEKG YAYVDFNYSG NLLASVGSNP DYTLTIWNWK EEQPILRTKA FSQEVFKVTF NPDKEEQLTT SGSGHIKFWE MAFTFTGLKL QGSLGRFGKT ITTDIEGYME LPDGKVLSGS EWGNMLLWEG GLIKVELCRG TSKSCHNGPI NQIMLYEGEV ITVGSDGYVR IWDFETIDTA DVIDETGLLE IEPINELQVD KNVNLFSMIK MNETGNNFWL AQDANGAIWK LDLSFSNITQ DPECLFSFHS GAIEAVAVSP LTYLMATTAL DCSVRIYDFA SKTPLAQMKF KQGGTALVWV PRMVNFTGAQ IIVGFEDGVV RILELYDPKG LTIFAGRKKI LDADIQLKQV FKPHTACVTA LAYERDGEIL ATGSKDQTVF FFEVERDYKP IGYINTPGPV CQLMWSPMSH PESTLLIICE NGYILEAPLP TIKQEEDDHD VVSYEIKDMC IKCFHFSSVK SKILRLIEIE KRERQRELKE KIREERRNKL AAEMGEDGEK EFQEEEEEKE EEEEEEEPLP EIFIPSTPSP ILCGFYSEPG KFWVSLGGYD SGFLYHCEFP PCDESSDFKE QKDEPIDVRY LADTEDNPIQ TITFNINKVM MFCGMKNGAI RVYVLNQNDP SLTSLVDYWH FNMHDNNYGC IKSIANSFDD RFLVTAGADG NIFVFNIFSE FMLRKDMKAK VPSPRFGIET EPIPEDIEDP KAYSIENARR KREHDKLMKE VGEIKARKRE QIKALRSEFC NLLEMNEKLP KHMQFKRTDF DVDSQIRAEM HRKTAFKIQQ VEKELAWEKE KHELGLMKLK NRFRDPLESD TIVVHAILSD HKISSYRLVQ PSKYSKFKRA SQSERKPSKL DRFEKEGPGR KDSQRDAGGS VTIQEESIIE KGKKFRPKTL SEIIVENQIE KTRKLILKAE RAQLKIQQRK KEWEELYKSK PGDDYEDPKD LQAIKEAQVY MGDFNLKTAP DYKIPEHMRI NAAKKEEELG HLDSLVHGNK RHMNKCILSL RDLKVAVVEE IQCLVQELKN IQSTLHISKH IPIPKIPQIH PEEVPEKRFQ YDEETLLNFK QQQMKSKDEK SPGVEQTGSG GPVGGFLKLS SRKDGDLTTR DSISRSSKAS TFSLDIPKCL EFEKAEPTDV ELEIMKRDEI KHVYMQQYLV NRIKELVVTF DAELRLLRHQ KLKLDTQMKL SDLHHVTLFQ EILLLKNFEK QENILQERVN SLDKEEQYMQ WKINETLKEM EEKKNEITKL QEQEKALYAG FQAAIGENNK FANFLMKVLK KKIKRVKKKE VEGDADEDEE SEESSEEESS LESDEDESES EDEVFDDSIC PTNCDVALFE LALHLREKRL DIEEALVEEK KIVDNLKKEY DTLSKKVKIV ATNLNAAEEA LEAYQREKQQ RLNELLVVIP LKLHQIEYVV FGEIPSDLSG TLVFSNHALR RLQERIHELQ EENSKQQKLN KEWRERRKQL IREKREMTKT IHKMEETVRQ LMISKFGRVV NLEALQTLSV NTTLEELKIR KLRKELANAK EMKMWEEKIA QMRWELMMKT KEHTRKLYQM NDLCIEKKKL DSRLNTLQNQ QGNAFQGPRE ADVVAREEVT ELIQLQAERI SALKEEIALL RRKGSLILPP IQSPREKEIQ PADL
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