About Zinc finger protein 778
Zinc finger protein 778 (ZNF778) is a protein
from Homo sapiens identified by UniProt accession
Q96MU6, 729 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Zinc finger protein 778 |
|---|
| UniProt accession | Q96MU6 |
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| Gene | ZNF778 |
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| Organism | Homo sapiens |
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| Length | 729 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- cystatin C measurement · score 0.23
- erythrocyte count · score 0.19
- hemoglobin measurement · score 0.19
- neutrophil count · score 0.17
- Global developmental delay · score 0.12
- Microcephaly · score 0.12
- Seizure · score 0.12
- obesity · score 0.12
- lymphocyte count · score 0.12
- hair colour measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96MU6-F1 | alphafold | PREDICTED | 63.49 | — |
Amino-acid sequence (729 residues)
MAAPDLAHGG HVSRDSVCLH EEQTQAAGMV AGWLINCYQD AVTFDDVAVD FTQEEWTLLD PSQRDLYRDV MLENYENLAS VEWRLKTKGP ALRQDRSWFR ASNETQTARS HNGGQLCDRT QCGEAFSEHS GLSTHVRTQN TGDSCVSNHY ERDFFIPCQK TLFKIGEQFS VLGQCGKAFS STPNVVSQQA CTRDRSLDYS SCGEVFLNQS YLQARAGSHN GEETWKWKPC GKALTHSMGC ATPVEMHAVR NPHVCRECGK AFRYTAYLTG RVQVHPGEKP CELEECGKAS PVSSSLTQHV RIHAAEKPCE CKECGKAFTG LSGLSKHVQT DPGQKPYECK DCGKACGGFY LLNEHGKTHT REKPFACVVC GKYFRNSSCL NNHVRIHTGI KPYTCSYCGK AFTVRCGLTR HVRTHTGEKP YTCKDCGKAF CTSSGLTEHV RTHTGEKPYE CKDCGKSFTV SSSLTEHARI HTGEKPYECK QCGKAFTGRS GLTKHMRTHT GEKPYECKDC GKAYNRVYLL NEHVKTHTEE KPFICTVCRK SFRNSSCLNK HIQIHTGIKP YECKDCGKTF TVSSSLTEHI RTHTGEKPYE CKVCGKAFTT SSHLIVHIRT HTGEKPYICK ECGKAFASSS HLIEHRRTHT GEKPYICNEC GKAFRASSHL HKHGRIHTGQ KPYKCKECGK AYNRFYLLKE HLKTYTEEQV FVCKDCGKSF KNSSCLNHHT QIHTDEKPF
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