About Janus kinase and microtubule-interacting protein 1
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) is a protein
from Homo sapiens identified by UniProt accession
Q96N16, 626 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Janus kinase and microtubule-interacting protein 1 |
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| UniProt accession | Q96N16 |
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| Gene | JAKMIP1 |
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| Organism | Homo sapiens |
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| Length | 626 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (48)
Diseases linked to this target (Open Targets).
- gut microbiome measurement · score 0.41
- Smith-Magenis syndrome · score 0.34
- neurodegenerative disease · score 0.26
- Intellectual disability · score 0.26
- Seizure · score 0.23
- PHF-tau measurement · score 0.12
- electroencephalogram measurement · score 0.10
- autism · score 0.05
- Asperger syndrome · score 0.04
- childhood disintegrative disorder · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96N16-F1 | alphafold | PREDICTED | 81.01 | — |
Amino-acid sequence (626 residues)
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE LEVRDSICCK LSNGADILFE PKLKFM
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