About Zinc finger protein 681
Zinc finger protein 681 (ZNF681) is a protein
from Homo sapiens identified by UniProt accession
Q96N22, 645 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Zinc finger protein 681 |
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| UniProt accession | Q96N22 |
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| Gene | ZNF681 |
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| Organism | Homo sapiens |
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| Length | 645 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- Testicular Germ Cell Tumor · score 0.17
- blood protein measurement · score 0.13
- cortical surface area measurement · score 0.08
- brain measurement · score 0.07
- insulin measurement · score 0.04
- X-linked severe congenital neutropenia · score 0.04
- Blackfan-Diamond anemia · score 0.04
- neutropenia, severe congenital, 2, autosomal dominant · score 0.04
- nonimmune chronic idiopathic neutropenia of adults · score 0.04
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96N22-F1 | alphafold | PREDICTED | 67.02 | — |
Amino-acid sequence (645 residues)
MEPLKFRDVA IEFSLEEWQC LDTIQQNLYR NVMLENYRNL VFLGIVVSKP DLITCLEQEK EPWTRKRHRM VAEPPVICSH FAQDFSPEQN IKDSFQKVTP RRYGKCEHEN LQLSKSVDEC KVQKGGYNGL NQCLPTTQSK IFQCDKYMKI FHKFSNLNGH KVRHTRKKPF KYKEFGKSFC IFSNLTQHKI ICTRVNFYKC EDCGKAFNGS SIFTKHKRIH IGEKSYICEE CGKACNQFTN LTTHKIIYTR DKLYKREECS KAFNLSSHIT THTIIHTGEN PYKREECDKA FNQSLTLTTH KIIHTREKLN EYKECGKAFN QSSHLTRHKI IHTGEKPYKC EECGKAFNQS SHLTRHKIIH TGEKPYRCEE CGKAFRQSSH LTTHKIIHTG EKPYKCEECG KAFNKSSHLT RHKSIHTGEK PYQCEKCGKA SNQSSNLTEH KNIHTEEKPY KCEECGKAFN QFSNLTTHKR IHTGEKPYKC EECGKAFNQS SILTTHKRIH TGEKSYKCEE CGKAFYRSSK LTEHKKIHTG EKPYTCEECG KAFNHSSHLA THKVIHTGEK PYQCEECGKA FNQSSHLTRH KRIHTGEKPY QCEKCGKAFN QSSNLTGHKK IHTGEKLYKP KRCNSDFENT SKFSKHKRNY AGEKS
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