About PWWP domain-containing protein 2A
PWWP domain-containing protein 2A (PWWP2A) is a protein
from Homo sapiens identified by UniProt accession
Q96N64, 755 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | PWWP domain-containing protein 2A |
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| UniProt accession | Q96N64 |
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| Gene | PWWP2A |
|---|
| Organism | Homo sapiens |
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| Length | 755 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (101)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- FEV/FVC ratio · score 0.30
- lysosomal storage disease · score 0.27
- lean body mass · score 0.27
- gastric adenocarcinoma · score 0.21
- nose morphology measurement · score 0.20
- hepatocellular carcinoma · score 0.18
- breast carcinoma · score 0.18
- chronic lymphocytic leukemia · score 0.18
- colorectal adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96N64-F1 | alphafold | PREDICTED | 57.71 | — |
Amino-acid sequence (755 residues)
MAAVAAEAAA TAASPGEGGA GEAEPEMEPI PGSEAGTDPL PVTATEASVP DGETDGQQSA PQADEPPLPP PPPPPGELAR SPEAVGPELE AEEKLSVRVA ESAAAAPQGG PELPPSPASP PEQPPAPEER EEPPLPQPVA PALVPPAGGD STVSQLIPGS EVRVTLDHII EDALVVSFRF GEKLFSGVLM DLSKRFGPHG IPVTVFPKRE YKDKPEAMPL QSNTFQEGTE VKCEANGAVP DDPSPVPHPE LSLAESLWTS KPPPLFHEGA PYPPPLFIRD TYNQSIPQPP PRKIKRPKRK MYREEPTSIM NAIKLRPRQV LCDKCKNSVV AEKKEIRKGS SATDSSKYED KKRRNESVTT VNKKLKTDHK VDGKNQNESQ KRNAVVKVSN IAHSRGRVVK VSAQANTSKA QLSTKKVLQS KNMDHAKARE VLKIAKEKAQ KKQNETSTSK NAHSKVHFTR RYQNPSSGSL PPRVRLKPQR YRNEENDSSL KTGLEKMRSG KMAPKPQSRC TSTRSAGEAP SENQSPSKGP EEASSEVQDT NEVHVPGDQD EPQTLGKKGS KNNISVYMTL NQKKSDSSSA SVCSIDSTDD LKSSNSECSS SESFDFPPGS MHAPSTSSTS SSSKEEKKLS NSLKMKVFSK NVSKCVTPDG RTICVGDIVW AKIYGFPWWP ARILTITVSR KDNGLLVRQE ARISWFGSPT TSFLALSQLS PFLENFQSRF NKKRKGLYRK AITEAAKAAK QLTPEVRALL TQFET
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