About Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 (MBOAT7) is a protein
from Homo sapiens identified by UniProt accession
Q96N66, 472 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 |
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| UniProt accession | Q96N66 |
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| Gene | MBOAT7 |
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| Organism | Homo sapiens |
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| Length | 472 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (108)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal recessive 57 · score 0.71
- genetic disorder · score 0.49
- autosomal recessive non-syndromic intellectual disability · score 0.46
- neurodegenerative disease · score 0.34
- phosphatidylinositol measurement · score 0.27
- Intellectual disability · score 0.27
- glioblastoma multiforme · score 0.18
- alkaline phosphatase measurement · score 0.15
- diacylglycerol 38:4 measurement · score 0.13
- platelet count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96N66-F1 | alphafold | PREDICTED | 91.99 | — |
Amino-acid sequence (472 residues)
MSPEEWTYLV VLLISIPIGF LFKKAGPGLK RWGAAAVGLG LTLFTCGPHT LHSLVTILGT WALIQAQPCS CHALALAWTF SYLLFFRALS LLGLPTPTPF TNAVQLLLTL KLVSLASEVQ DLHLAQRKEM ASGFSKGPTL GLLPDVPSLM ETLSYSYCYV GIMTGPFFRY RTYLDWLEQP FPGAVPSLRP LLRRAWPAPL FGLLFLLSSH LFPLEAVRED AFYARPLPAR LFYMIPVFFA FRMRFYVAWI AAECGCIAAG FGAYPVAAKA RAGGGPTLQC PPPSSPEKAA SLEYDYETIR NIDCYSTDFC VRVRDGMRYW NMTVQWWLAQ YIYKSAPARS YVLRSAWTML LSAYWHGLHP GYYLSFLTIP LCLAAEGRLE SALRGRLSPG GQKAWDWVHW FLKMRAYDYM CMGFVLLSLA DTLRYWASIY FCIHFLALAA LGLGLALGGG SPSRRKAASQ PTSLAPEKLR EE
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