About Inactive sodium-dependent neutral amino acid transporter B(0)AT3
Inactive sodium-dependent neutral amino acid transporter B(0)AT3 (SLC6A18) is a protein
from Homo sapiens identified by UniProt accession
Q96N87, 628 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Inactive sodium-dependent neutral amino acid transporter B(0)AT3 |
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| UniProt accession | Q96N87 |
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| Gene | SLC6A18 |
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| Organism | Homo sapiens |
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| Length | 628 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- Sensorineural hearing impairment · score 0.37
- colorectal cancer · score 0.34
- creatinine measurement · score 0.32
- colorectal adenoma · score 0.28
- hemoglobin measurement · score 0.24
- cutaneous melanoma · score 0.18
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.08
- focal segmental glomerulosclerosis · score 0.08
- IGA glomerulonephritis · score 0.07
- nail-patella-like renal disease · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96N87-F1 | alphafold | PREDICTED | 90.50 | — |
Amino-acid sequence (628 residues)
MAHAPEPDPA ACDLGDERPK WDNKAQYLLS CTGFAVGLGN IWRFPYLCQT YGGGAFLIPY VIALVFEGIP IFHVELAIGQ RLRKGSVGVW TAISPYLSGV GLGCVTLSFL ISLYYNTIVA WVLWYLLNSF QHPLPWSSCP PDLNRTGFVE ECQGSSAVSY FWYRQTLNIT ADINDSGSIQ WWLLICLAAS WAVVYMCVIR GIETTGKVIY FTALFPYLVL TIFLIRGLTL PGATKGLIYL FTPNMHILQN PRVWLDAATQ IFFSLSLAFG GHIAFASYNS PRNDCQKDAV VIALVNRMTS LYASIAVFSV LGFKATNDYE HCLDRNILSL INDFDFPEQS ISRDDYPAVL MHLNATWPKR VAQLPLKACL LEDFLDKSAS GPGLAFVVFT ETDLHMPGAP VWAMLFFGML FTLGLSTMFG TVEAVITPLL DVGVLPRWVP KEALTGLVCL VCFLSATCFT LQSGNYWLEI FDNFAASPNL LMLAFLEVVG VVYVYGMKRF CDDIAWMTGR RPSPYWRLTW RVVSPLLLTI FVAYIILLFW KPLRYKAWNP KYELFPSRQE KLYPGWARAA CVLLSLLPVL WVPVAALAQL LTRRRRTWRD RDARPDTDMR PDTDTRPDTD MRPDTDMR
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