t-SNARE domain-containing protein 1 (TSNARE1)

About t-SNARE domain-containing protein 1

t-SNARE domain-containing protein 1 (TSNARE1) is a protein from Homo sapiens identified by UniProt accession Q96NA8, 513 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	t-SNARE domain-containing protein 1
UniProt accession	Q96NA8
Gene	TSNARE1
Organism	Homo sapiens
Length	513 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.48
body mass index · score 0.43
self reported educational attainment · score 0.41
systolic blood pressure · score 0.39
cognitive function measurement · score 0.38
mathematical ability · score 0.38
feeling tense measurement · score 0.37
risk-taking behaviour · score 0.37
bipolar disorder · score 0.37
intelligence · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96NA8-F1	alphafold	PREDICTED	67.76	—

Amino-acid sequence (513 residues)

MSYGSIARGG GLGSRGPFGG PSRQGCQPLE CARCWTEYGI RHFPCPSPES KLQNRCVGKD GEGDLGPAGT PIVPRARKRG PGVAPEGSRM PEPTSSPTIG PRKDSAAGPH GRMAGPSTTR AKKRKPNFCP QETEVLVSKV SKHHQLLFGT GLLKAEPTRR YRVWSRILQA VNALGYCRRD VVDLKHKWRD LRAVVRRKLG DLRKAAHGPS PGSGKPQALA LTPVEQVVAK TFSCQALPSE GFSLEPPRAT QVDPCNLQEL FQEMSANVFR INSSVTSLER SLQSLGTPSD TQELRDSLHT AQQETNKTIA ASASSVKQMA ELLRSSCPQE RLQQERPQLD RLKTQLSDAI QCYGVVQKKI AEKSRALLPM AQRGSKQSPQ APFAELADDE KVFNGSDNMW QGQEQALLPD ITEEDLEAIR LREEAILQME SNLLDVNQII KDLASMVSEQ GEAVDSIEAS LEAASSHAEA ARQLLAGASR HQLQRHKIKC CFLSAGVTAL LVIIIIIATS VRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards