About FERM domain-containing protein 6
FERM domain-containing protein 6 (FRMD6) is a protein
from Homo sapiens identified by UniProt accession
Q96NE9, 622 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | FERM domain-containing protein 6 |
|---|
| UniProt accession | Q96NE9 |
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| Gene | FRMD6 |
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| Organism | Homo sapiens |
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| Length | 622 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- cleft lip · score 0.37
- Cleft palate · score 0.37
- neurodegenerative disease · score 0.34
- protein measurement · score 0.34
- arterial stiffness measurement · score 0.34
- drug use measurement · score 0.08
- glioblastoma multiforme · score 0.07
- melanoma · score 0.05
- hepatocellular carcinoma · score 0.04
- spinocerebellar ataxia, autosomal recessive 24 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96NE9-F1 | alphafold | PREDICTED | 66.21 | — |
Amino-acid sequence (622 residues)
MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR LKDCHLFGLS VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI DQFGPPMIIH FRVQYYVENG RLISDRAARY YYYWHLRKQV LHSQCVLREE AYFLLAAFAL QADLGNFKRN KHYGKYFEPE AYFPSWVVSK RGKDYILKHI PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK REIEASLTLG LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY ISDNLDLDMD QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD TKPRDTGPED SYSSSAIHRK LKTCSSMTSH GSSHTSGVES GGKDRLEEDL QDDEIEMLVD DPRDLEQMNE ESLEVSPDMC IYITEDMLMS RKLNGHSGLI VKEIGSSTSS SSETVVKLRG QSTDSLPQTI CRKPKTSTDR HSLSLDDIRL YQKDFLRIAG LCQDTAQSYT FGCGHELDEE GLYCNSCLAQ QCINIQDAFP VKRTSKYFSL DLTHDEVPEF VV
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