Zinc finger protein 558 (ZNF558)

About Zinc finger protein 558

Zinc finger protein 558 (ZNF558) is a protein from Homo sapiens identified by UniProt accession Q96NG5, 402 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Zinc finger protein 558
UniProt accession	Q96NG5
Gene	ZNF558
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

body weight · score 0.15
carpal tunnel syndrome · score 0.12
hyperinsulinism due to INSR deficiency · score 0.04
cancer antigen 125 measurement · score 0.04
hyperinsulinism due to glucokinase deficiency · score 0.03
cystic fibrosis · score 0.01
Leber congenital amaurosis · score 0.00
hepatocellular carcinoma · score 0.00
central nervous system cancer · score 0.00
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96NG5-F1	alphafold	PREDICTED	73.53	—

Amino-acid sequence (402 residues)

MAAVILPSTA APSSLFPASQ QKGHTQGGEL VNELLTSWLR GLVTFEDVAV EFTQEEWALL DPAQRTLYRD VMLENCRNLA SLGCRVNKPS LISQLEQDKK VVTEERGILP STCPDLETLL KAKWLTPKKN VFRKEQSKGV KTERSHRGVK LNECNQCFKV FSTKSNLTQH KRIHTGEKPY DCSQCGKSFS SRSYLTIHKR IHNGEKPYEC NHCGKAFSDP SSLRLHLRIH TGEKPYECNQ CFHVFRTSCN LKSHKRIHTG ENHHECNQCG KAFSTRSSLT GHNSIHTGEK PYECHDCGKT FRKSSYLTQH VRTHTGEKPY ECNECGKSFS SSFSLTVHKR IHTGEKPYEC SDCGKAFNNL SAVKKHLRTH TGEKPYECNH CGKSFTSNSY LSVHKRIHNR WI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards