About Kelch-like protein 32
Kelch-like protein 32 (KLHL32) is a protein
from Homo sapiens identified by UniProt accession
Q96NJ5, 620 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Kelch-like protein 32 |
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| UniProt accession | Q96NJ5 |
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| Gene | KLHL32 |
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| Organism | Homo sapiens |
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| Length | 620 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- body mass index · score 0.45
- waist-hip ratio · score 0.40
- self reported educational attainment · score 0.38
- mathematical ability · score 0.37
- gait measurement · score 0.32
- cognitive function measurement · score 0.30
- MODY · score 0.08
- physical activity measurement · score 0.06
- Griscelli syndrome type 3 · score 0.05
- diabetes mellitus, transient neonatal, 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96NJ5-F1 | alphafold | PREDICTED | 89.87 | — |
Amino-acid sequence (620 residues)
MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE QKFHAHKAVL AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA YTGQILLEPG VIQDVLAAGS HLQLLELLNL CSHYLIQELN SFNYLDLYRL ADLFNLTLLE KAVIDFLVKH LSELLKSRPE EVLTLPYCLL QEVLKSDRLT SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT LHTVALSHPL VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV AGGEVEHASG RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL YAVGGRNELR QVLPTVERYC PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI SGGVTNTAQY QNRLMVYEPN QNKWISRSPM LQRRVYHSMA AVQRKLYVLG GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES GVAVHNGRIY LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP YFTCPNLQTL QVPHHRIGTI
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