Neurogenic differentiation factor 6 (NEUROD6)

About Neurogenic differentiation factor 6

Neurogenic differentiation factor 6 (NEUROD6) is a protein from Homo sapiens identified by UniProt accession Q96NK8, 337 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Neurogenic differentiation factor 6
UniProt accession	Q96NK8
Gene	NEUROD6
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

age at first sexual intercourse measurement · score 0.38
self reported educational attainment · score 0.27
emotional symptom measurement · score 0.27
attention deficit hyperactivity disorder · score 0.26
antisocial behaviour measurement · score 0.26
substance abuse · score 0.26
brain volume measurement · score 0.25
neuroimaging measurement · score 0.25
hippocampal tail volume · score 0.25
smoking status measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96NK8-F1	alphafold	PREDICTED	62.10	—

Amino-acid sequence (337 residues)

MLTLPFDESV VMPESQMCRK FSRECEDQKQ IKKPESFSKQ IVLRGKSIKR APGEETEKEE EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT RSPYSTFYPP YHSPELTTPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards