About Proton-coupled folate transporter
Proton-coupled folate transporter (SLC46A1) is a protein
from Homo sapiens identified by UniProt accession
Q96NT5, 459 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Proton-coupled folate transporter |
|---|
| UniProt accession | Q96NT5 |
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| Gene | SLC46A1 |
|---|
| Organism | Homo sapiens |
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| Length | 459 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (92)
Diseases linked to this target (Open Targets).
- hereditary folate malabsorption · score 0.83
- genetic disorder · score 0.41
- methylmalonic aciduria and homocystinuria type cblC · score 0.27
- Methylmalonic acidemia with homocystinuria · score 0.27
- Methylmalonic acidemia with homocystinuria, type cblC · score 0.27
- aspartylglucosaminuria · score 0.27
- semaphorin-3A measurement · score 0.22
- interleukin 5 measurement · score 0.21
- calcium/calmodulin-dependent protein kinase type 1D measurement · score 0.21
- low density lipoprotein cholesterol measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96NT5-F1 | alphafold | PREDICTED | 83.08 | — |
Amino-acid sequence (459 residues)
MEGSASPPEK PRARPAAAVL CRGPVEPLVF LANFALVLQG PLTTQYLWHR FSADLGYNGT RQRGGCSNRS ADPTMQEVET LTSHWTLYMN VGGFLVGLFS STLLGAWSDS VGRRPLLVLA SLGLLLQALV SVFVVQLQLH VGYFVLGRIL CALLGDFGGL LAASFASVAD VSSSRSRTFR MALLEASIGV AGMLASLLGG HWLRAQGYAN PFWLALALLI AMTLYAAFCF GETLKEPKST RLFTFRHHRS IVQLYVAPAP EKSRKHLALY SLAIFVVITV HFGAQDILTL YELSTPLCWD SKLIGYGSAA QHLPYLTSLL ALKLLQYCLA DAWVAEIGLA FNILGMVVFA FATITPLMFT GYGLLFLSLV ITPVIRAKLS KLVRETEQGA LFSAVACVNS LAMLTASGIF NSLYPATLNF MKGFPFLLGA GLLLIPAVLI GMLEKADPHL EFQQFPQSP
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