28S rRNA (cytosine-C(5))-methyltransferase (NSUN5)

About 28S rRNA (cytosine-C(5))-methyltransferase

28S rRNA (cytosine-C(5))-methyltransferase (NSUN5) is a protein from Homo sapiens identified by UniProt accession Q96P11, 429 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	28S rRNA (cytosine-C(5))-methyltransferase
UniProt accession	Q96P11
Gene	NSUN5
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
hepatocellular carcinoma · score 0.10
nonpapillary renal cell carcinoma · score 0.08
glioblastoma multiforme · score 0.08
neoplasm · score 0.08
beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.06
acute lymphoblastic leukemia · score 0.06
hemoglobin E-beta-thalassemia syndrome · score 0.05
X-linked sideroblastic anemia 1 · score 0.05
hemoglobin D disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96P11-F1	alphafold	PREDICTED	91.45	—

Amino-acid sequence (429 residues)

MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA VIERVEVPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards