About Cytosolic 5'-nucleotidase 1B
Cytosolic 5'-nucleotidase 1B (NT5C1B) is a protein
from Homo sapiens identified by UniProt accession
Q96P26, 610 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Cytosolic 5'-nucleotidase 1B |
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| UniProt accession | Q96P26 |
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| Gene | NT5C1B |
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| Organism | Homo sapiens |
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| Length | 610 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- peak expiratory flow · score 0.26
- glomerular filtration rate · score 0.25
- systolic blood pressure · score 0.25
- urate measurement · score 0.23
- benign prostatic hyperplasia · score 0.23
- diverticulitis · score 0.22
- diverticular disease · score 0.22
- creatinine measurement · score 0.22
- diastolic blood pressure · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96P26-F1 | alphafold | PREDICTED | 63.45 | — |
Amino-acid sequence (610 residues)
MSQTSLKQKK NEPGMRSSKE SLEAEKRKES DKTGVRLSNQ MRRAVNPNHS LRCCPFQGHS SCRRCLCAAE GTALGPCHTI RIYIHMCLLW EQGQQITMMR GSQESSLRKT DSRGYLVRSQ WSRISRSPST KAPSIDEPRS RNTSAKLPSS STSSRTPSTS PSLHDSSPPP LSGQPSLQPP ASPQLPRSLD SRPPTPPEPD PGSRRSTKMQ ENPEAWAQGI VREIRQTRDS QPLEYSRTSP TEWKSSSQRR GIYPASTQLD RNSLSEQQQQ QREDEDDYEA AYWASMRSFY EKNPSCSRPW PPKPKNAITI ALSSCALFNM VDGRKIYEQE GLEKYMEYQL TNENVILTPG PAFRFVKALQ YVNARLRDLY PDEQDLFDIV LMTNNHAQVG VRLINSVNHY GLLIDRFCLT GGKDPIGYLK AYLTNLYIAA DSEKVQEAIQ EGIASATMFD GAKDMAYCDT QLRVAFDGDA VLFSDESEHF TKEHGLDKFF QYDTLCESKP LAQGPLKGFL EDLGRLQKKF YAKNERLLCP IRTYLVTARS AASSGARVLK TLRRWGLEID EALFLAGAPK SPILVKIRPH IFFDDHMFHI EGAQRLGSIA AYGFNKKFSS
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