About Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) is a protein
from Homo sapiens identified by UniProt accession
Q96P47, 875 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 |
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| UniProt accession | Q96P47 |
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| Gene | AGAP3 |
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| Organism | Homo sapiens |
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| Length | 875 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.28
- cortical surface area measurement · score 0.27
- vital capacity · score 0.22
- brain measurement · score 0.22
- body mass index · score 0.20
- FEV/FVC ratio · score 0.18
- creatinine measurement · score 0.17
- lean body mass · score 0.16
- IGF-1 measurement · score 0.13
- heel bone mineral density · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96P47-F1 | alphafold | PREDICTED | 70.00 | — |
Amino-acid sequence (875 residues)
MNFQAGGGQS PQQQQQLAGG PPQQFALSNS AAIRAEIQRF ESVHPNIYAI YDLIERIEDL ALQNQIREHV ISIEDSFVNS QEWTLSRSVP ELKVGIVGNL SSGKSALVHR YLTGTYVQEE SPEGGRFKKE IVVDGQSYLL LIRDEGGPPE LQFAAWVDAV VFVFSLEDEI SFQTVYNYFL RLCSFRNASE VPMVLVGTQD AISAANPRVI DDSRARKLST DLKRCTYYET CATYGLNVER VFQDVAQKVV ALRKKQQLAI GPCKSLPNSP SHSAVSAASI PAVHINQATN GGGSAFSDYS SSVPSTPSIS QRELRIETIA ASSTPTPIRK QSKRRSNIFT SRKGADLDRE KKAAECKVDS IGSGRAIPIK QGILLKRSGK SLNKEWKKKY VTLCDNGLLT YHPSLHDYMQ NIHGKEIDLL RTTVKVPGKR LPRATPATAP GTSPRANGLS VERSNTQLGG GTGAPHSASS ASLHSERPLS SSAWAGPRPE GLHQRSCSVS SADQWSEATT SLPPGMQHPA SGPAEVLSSS PKLDPPPSPH SNRKKHRRKK STGTPRPDGP SSATEEAEES FEFVVVSLTG QTWHFEASTA EERELWVQSV QAQILASLQG CRSAKDKTRL GNQNAALAVQ AVRTVRGNSF CIDCDAPNPD WASLNLGALM CIECSGIHRH LGAHLSRVRS LDLDDWPPEL LAVMTAMGNA LANSVWEGAL GGYSKPGPDA CREEKERWIR AKYEQKLFLA PLPSSDVPLG QQLLRAVVED DLRLLVMLLA HGSKEEVNET YGDGDGRTAL HLSSAMANVV FTQLLIWYGV DVRSRDARGL TPLAYARRAG SQECADILIQ HGCPGEGCGL APTPNREPAN GTNPSAELHR SPSLL
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