About Cation channel sperm-associated protein 2
Cation channel sperm-associated protein 2 (CATSPER2) is a protein
from Homo sapiens identified by UniProt accession
Q96P56, 530 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Cation channel sperm-associated protein 2 |
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| UniProt accession | Q96P56 |
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| Gene | CATSPER2 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (134)
Diseases linked to this target (Open Targets).
- deafness-infertility syndrome · score 0.39
- Rare genetic deafness · score 0.34
- hearing loss, autosomal recessive · score 0.34
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.23
- monocyte percentage of leukocytes · score 0.17
- breast adenocarcinoma · score 0.16
- squamous cell lung carcinoma · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- platelet count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96P56-F1 | alphafold | PREDICTED | 69.26 | — |
Amino-acid sequence (530 residues)
MAAYQQEEQM QLPRADAIRS RLIDTFSLIE HLQGLSQAVP RHTIRELLDP SRQKKLVLGD QHQLVRFSIK PQRIEQISHA QRLLSRLHVR CSQRPPLSLW AGWVLECPLF KNFIIFLVFL NTIILMVEIE LLESTNTKLW PLKLTLEVAA WFILLIFILE ILLKWLSNFS VFWKSAWNVF DFVVTMLSLL PEVVVLVGVT GQSVWLQLLR ICRVLRSLKL LAQFRQIQII ILVLVRALKS MTFLLMLLLI FFYIFAVTGV YVFSEYTRSP RQDLEYHVFF SDLPNSLVTV FILFTLDHWY ALLQDVWKVP EVSRIFSSIY FILWLLLGSI IFRSIIVAMM VTNFQNIRKE LNEEMARREV QLKADMFKRQ IIQRRKNMSH EALTSSHSKI EDSSRGASQQ RESLDLSEVS EVESNYGATE EDLITSASKT EETLSKKREY QSSSCVSSTS SSYSSSSESR FSESIGRLDW ETLVHENLPG LMEMDQDDRV WPRDSLFRYF ELLEKLQYNL EERKKLQEFA VQALMNLEDK
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