Serpin B12 (SERPINB12)

About Serpin B12

Serpin B12 (SERPINB12) is a protein from Homo sapiens identified by UniProt accession Q96P63, 405 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Serpin B12
UniProt accession	Q96P63
Gene	SERPINB12
Organism	Homo sapiens
Length	405 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.35
eosinophil percentage of leukocytes · score 0.18
neutrophil percentage of granulocytes · score 0.13
sum of eosinophil and basophil counts · score 0.12
acute myeloid leukemia · score 0.10
non-small cell lung carcinoma · score 0.07
eosinophil percentage of granulocytes · score 0.07
neoplasm · score 0.06
Asperger syndrome · score 0.05
Gollop-Wolfgang complex · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96P63-F1	alphafold	PREDICTED	88.69	—

Amino-acid sequence (405 residues)

MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS AHQIDEVLHF NEFSQNESKE PDPCLKSNKQ KAGSLNNESG LVSCYFGQLL SKLDRIKTDY TLSIANRLYG EQEFPICQEY LDGVIQFYHT TIESVDFQKN PEKSRQEINF WVECQSQGKI KELFSKDAIN AETVLVLVNA VYFKAKWETY FDHENTVDAP FCLNANENKS VKMMTQKGLY RIGFIEEVKA QILEMRYTKG KLSMFVLLPS HSKDNLKGLE ELERKITYEK MVAWSSSENM SEESVVLSFP RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY LSKIIHKTFV EVDENGTQAA AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG RVCSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards