About Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 (AGAP4) is a protein
from Homo sapiens identified by UniProt accession
Q96P64, 663 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 |
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| UniProt accession | Q96P64 |
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| Gene | AGAP4 |
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| Organism | Homo sapiens |
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| Length | 663 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.06
- reticulocyte measurement · score 0.06
- mean corpuscular hemoglobin concentration · score 0.06
- mean corpuscular hemoglobin · score 0.05
- erythrocyte count · score 0.05
- high density lipoprotein cholesterol measurement · score 0.04
- total cholesterol measurement · score 0.03
- alcohol consumption measurement · score 0.03
- alcohol drinking · score 0.03
- red blood cell density measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96P64-F1 | alphafold | PREDICTED | 63.21 | — |
Amino-acid sequence (663 residues)
MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV STVRFSQQYS LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRS LSIPDEQLHS FAVSTVHIMK KRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISTSKSNGL SKDMDTGLGD SICFSPSISS TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL ASLQSCESSK SKSQLTSQSK AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS GIHRSLGTRL SRVRSLELDD WPVELRKVMS SIGNDLANSI WEGSSQGQTK PSEKSTREEK ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD KCV
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