Pyroglutamylated RF-amide peptide receptor (QRFPR)

About Pyroglutamylated RF-amide peptide receptor

Pyroglutamylated RF-amide peptide receptor (QRFPR) is a protein from Homo sapiens identified by UniProt accession Q96P65, 431 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.

Target properties

Protein name	Pyroglutamylated RF-amide peptide receptor
UniProt accession	Q96P65
Gene	QRFPR
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (118)

Diseases linked to this target (Open Targets).

body weight · score 0.34
autoimmune thyroid disease · score 0.29
type 1 diabetes mellitus · score 0.29
glioblastoma multiforme · score 0.26
metabolite measurement · score 0.26
breast adenocarcinoma · score 0.25
protein measurement · score 0.25
head and neck squamous cell carcinoma · score 0.20
cutaneous melanoma · score 0.18
lung adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96P65-F1	alphafold	PREDICTED	78.76	—

Amino-acid sequence (431 residues)

MQALNITPEQ FSRLLRDHNL TREQFIALYR LRPLVYTPEL PGRAKLALVL TGVLIFALAL FGNALVFYVV TRSKAMRTVT NIFICSLALS DLLITFFCIP VTMLQNISDN WLGGAFICKM VPFVQSTAVV TEILTMTCIA VERHQGLVHP FKMKWQYTNR RAFTMLGVVW LVAVIVGSPM WHVQQLEIKY DFLYEKEHIC CLEEWTSPVH QKIYTTFILV ILFLLPLMVM LILYSKIGYE LWIKKRVGDG SVLRTIHGKE MSKIARKKKR AVIMMVTVVA LFAVCWAPFH VVHMMIEYSN FEKEYDDVTI KMIFAIVQII GFSNSICNPI VYAFMNENFK KNVLSAVCYC IVNKTFSPAQ RHGNSGITMM RKKAKFSLRE NPVEETKGEA FSDGNIEVKL CEQTEEKKKL KRHLALFRSE LAENSPLDSG H

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards