Probable G-protein coupled receptor 101 (GPR101)

About Probable G-protein coupled receptor 101

Probable G-protein coupled receptor 101 (GPR101) is a protein from Homo sapiens identified by UniProt accession Q96P66, 508 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 101
UniProt accession	Q96P66
Gene	GPR101
Organism	Homo sapiens
Length	508 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

growth hormone-secreting pituitary adenoma · score 0.46
acromegaly · score 0.37
age at onset · score 0.03
Myopia · score 0.03
pulse pressure measurement · score 0.03
systolic blood pressure · score 0.03
Abnormality of refraction · score 0.03
Pituitary Gland Adenoma · score 0.02
familial isolated pituitary adenoma · score 0.02
infection · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96P66-F1	alphafold	PREDICTED	68.76	—

Amino-acid sequence (508 residues)

MTSTCTNSTR ESNSSHTCMP LSKMPISLAH GIIRSTVLVI FLAASFVGNI VLALVLQRKP QLLQVTNRFI FNLLVTDLLQ ISLVAPWVVA TSVPLFWPLN SHFCTALVSL THLFAFASVN TIVVVSVDRY LSIIHPLSYP SKMTQRRGYL LLYGTWIVAI LQSTPPLYGW GQAAFDERNA LCSMIWGASP SYTILSVVSF IVIPLIVMIA CYSVVFCAAR RQHALLYNVK RHSLEVRVKD CVENEDEEGA EKKEEFQDES EFRRQHEGEV KAKEGRMEAK DGSLKAKEGS TGTSESSVEA RGSEEVRESS TVASDGSMEG KEGSTKVEEN SMKADKGRTE VNQCSIDLGE DDMEFGEDDI NFSEDDVEAV NIPESLPPSR RNSNSNPPLP RCYQCKAAKV IFIIIFSYVL SLGPYCFLAV LAVWVDVETQ VPQWVITIII WLFFLQCCIH PYVYGYMHKT IKKEIQDMLK KFFCKEKPPK EDSHPDLPGT EGGTEGKIVP SYDSATFP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards