2-oxoglutarate receptor 1 (OXGR1)

About 2-oxoglutarate receptor 1

2-oxoglutarate receptor 1 (OXGR1) is a protein from Homo sapiens identified by UniProt accession Q96P68, 337 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	2-oxoglutarate receptor 1
UniProt accession	Q96P68
Gene	OXGR1
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

nephrolithiasis, calcium oxalate, 2, with or without nephrocalcinosis · score 0.57
neurodegenerative disease · score 0.33
ovarian cancer · score 0.23
age at first sexual intercourse measurement · score 0.17
breast adenocarcinoma · score 0.10
total cholesterol measurement · score 0.07
response to selective serotonin reuptake inhibitor · score 0.07
pentosuria · score 0.05
colorectal adenocarcinoma · score 0.04
Dent disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96P68-F1	alphafold	PREDICTED	86.37	—

Amino-acid sequence (337 residues)

MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG NAVVISTYIF KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI FGDFMCKFIR FSFHFNLYSS ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA VVACAVVWII SLVAVIPMTF LITSTNRTNR SACLDLTSSD ELNTIKWYNL ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR RLTILLLLAF YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards