G-protein coupled receptor 78 (GPR78)

About G-protein coupled receptor 78

G-protein coupled receptor 78 (GPR78) is a protein from Homo sapiens identified by UniProt accession Q96P69, 363 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	G-protein coupled receptor 78
UniProt accession	Q96P69
Gene	GPR78
Organism	Homo sapiens
Length	363 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

body height · score 0.36
appendicular lean mass · score 0.28
systemic lupus erythematosus · score 0.28
body fat distribution · score 0.27
neuroblastoma · score 0.26
forced expiratory volume · score 0.24
sitting height measurement · score 0.22
vital capacity · score 0.13
Abnormality of refraction · score 0.13
non-small cell lung carcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96P69-F1	alphafold	PREDICTED	84.62	—

Amino-acid sequence (363 residues)

MGPGEALLAG LLVMVLAVAL LSNALVLLCC AYSAELRTRA SGVLLVNLSL GHLLLAALDM PFTLLGVMRG RTPSAPGACQ VIGFLDTFLA SNAALSVAAL SADQWLAVGF PLRYAGRLRP RYAGLLLGCA WGQSLAFSGA ALGCSWLGYS SAFASCSLRL PPEPERPRFA AFTATLHAVG FVLPLAVLCL TSLQVHRVAR RHCQRMDTVT MKALALLADL HPSVRQRCLI QQKRRRHRAT RKIGIAIATF LICFAPYVMT RLAELVPFVT VNAQWGILSK CLTYSKAVAD PFTYSLLRRP FRQVLAGMVH RLLKRTPRPA STHDSSLDVA GMVHQLLKRT PRPASTHNGS VDTENDSCLQ QTH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards