About N-acetylneuraminate (7)9-O-acetyltransferase
N-acetylneuraminate (7)9-O-acetyltransferase (CASD1) is a protein
from Homo sapiens identified by UniProt accession
Q96PB1, 797 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | N-acetylneuraminate (7)9-O-acetyltransferase |
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| UniProt accession | Q96PB1 |
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| Gene | CASD1 |
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| Organism | Homo sapiens |
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| Length | 797 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- breast carcinoma · score 0.23
- schizophrenia · score 0.11
- blood protein measurement · score 0.11
- carpal tunnel syndrome · score 0.08
- breast cancer · score 0.07
- lung adenocarcinoma · score 0.05
- heel bone mineral density · score 0.04
- melanoma · score 0.02
- cancer · score 0.02
- acute lymphoblastic leukemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PB1-F1 | alphafold | PREDICTED | 87.76 | — |
Amino-acid sequence (797 residues)
MAALAYNLGK REINHYFSVR SAKVLALVAV LLLAACHLAS RRYRGNDSCE YLLSSGRFLG EKVWQPHSCM MHKYKISEAK NCLVDKHIAF IGDSRIRQLF YSFVKIINPQ FKEEGNKHEN IPFEDKTASV KVDFLWHPEV NGSMKQCIKV WTEDSIAKPH VIVAGAATWS IKIHNGSSEA LSQYKMNITS IAPLLEKLAK TSDVYWVLQD PVYEDLLSEN RKMITNEKID AYNEAAVSIL NSSTRNSKSN VKMFSVSKLI AQETIMESLD GLHLPESSRE TTAMILMNVY CNKILKPVDG SCCQPRPPVT LIQKLAACFF TLSIIGYLIF YIIHRNAHRK NKPCTDLESG EEKKNIINTP VSSLEILLQS FCKLGLIMAY FYMCDRANLF MKENKFYTHS SFFIPIIYIL VLGVFYNENT KETKVLNREQ TDEWKGWMQL VILIYHISGA STFLPVYMHI RVLVAAYLFQ TGYGHFSYFW IKGDFGIYRV CQVLFRLNFL VVVLCIVMDR PYQFYYFVPL VTVWFMVIYV TLALWPQIIQ KKANGNCFWH FGLLLKLGFL LLFICFLAYS QGAFEKIFSL WPLSKCFELK GNVYEWWFRW RLDRYVVFHG MLFAFIYLAL QKRQILSEGK GEPLFSNKIS NFLLFISVVS FLTYSIWASS CKNKAECNEL HPSVSVVQIL AFILIRNIPG YARSVYSSFF AWFGKISLEL FICQYHIWLA ADTRGILVLI PGNPMLNIIV STFIFVCVAH EISQITNDLA QIIIPKDNSS LLKRLACIAA FFCGLLILSS IQDKSKH
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