About N-acetylmuramoyl-L-alanine amidase
N-acetylmuramoyl-L-alanine amidase (PGLYRP2) is a protein
from Homo sapiens identified by UniProt accession
Q96PD5, 576 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | N-acetylmuramoyl-L-alanine amidase |
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| UniProt accession | Q96PD5 |
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| Gene | PGLYRP2 |
|---|
| Organism | Homo sapiens |
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| Length | 576 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (120)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.34
- lung adenocarcinoma · score 0.18
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.17
- endometrial cancer · score 0.15
- squamous cell lung carcinoma · score 0.14
- head and neck squamous cell carcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- hepatocellular carcinoma · score 0.08
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PD5-F1 | alphafold | PREDICTED | 78.65 | — |
Amino-acid sequence (576 residues)
MAQGVLWILL GLLLWSDPGT ASLPLLMDSV IQALAELEQK VPAAKTRHTA SAWLMSAPNS GPHNRLYHFL LGAWSLNATE LDPCPLSPEL LGLTKEVARH DVREGKEYGV VLAPDGSTVA VEPLLAGLEA GLQGRRVINL PLDSMAAPWE TGDTFPDVVA IAPDVRATSS PGLRDGSPDV TTADIGANTP DATKGCPDVQ ASLPDAKAKS PPTMVDSLLA VTLAGNLGLT FLRGSQTQSH PDLGTEGCWD QLSAPRTFTL LDPKASLLTM AFLNGALDGV ILGDYLSRTP EPRPSLSHLL SQYYGAGVAR DPGFRSNFRR QNGAALTSAS ILAQQVWGTL VLLQRLEPVH LQLQCMSQEQ LAQVAANATK EFTEAFLGCP AIHPRCRWGA APYRGRPKLL QLPLGFLYVH HTYVPAPPCT DFTRCAANMR SMQRYHQDTQ GWGDIGYSFV VGSDGYVYEG RGWHWVGAHT LGHNSRGFGV AIVGNYTAAL PTEAALRTVR DTLPSCAVRA GLLRPDYALL GHRQLVRTDC PGDALFDLLR TWPHFTATVK PRPARSVSKR SRREPPPRTL PATDLQ
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