2-acylglycerol O-acyltransferase 1 (MOGAT1)

About 2-acylglycerol O-acyltransferase 1

2-acylglycerol O-acyltransferase 1 (MOGAT1) is a protein from Homo sapiens identified by UniProt accession Q96PD6, 335 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	2-acylglycerol O-acyltransferase 1
UniProt accession	Q96PD6
Gene	MOGAT1
Organism	Homo sapiens
Length	335 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.24
sex hormone-binding globulin measurement · score 0.12
balding measurement · score 0.12
facial morphology measurement · score 0.12
hair shape measurement · score 0.09
chin morphology measurement · score 0.09
age-related macular degeneration · score 0.08
X-linked retinal dysplasia · score 0.07
Familial exudative vitreoretinopathy · score 0.06
severe early-childhood-onset retinal dystrophy · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96PD6-F1	alphafold	PREDICTED	93.99	—

Amino-acid sequence (335 residues)

MKVEFAPLNI QLARRLQTVA VLQWVLKYLL LGPMSIGITV MLIIHNYLFL YIPYLMWLYF DWHTPERGGR RSSWIKNWTL WKHFKDYFPI HLIKTQDLDP SHNYIFGFHP HGIMAVGAFG NFSVNYSDFK DLFPGFTSYL HVLPLWFWCP VFREYVMSVG LVSVSKKSVS YMVSKEGGGN ISVIVLGGAK ESLDAHPGKF TLFIRQRKGF VKIALTHGAS LVPVVSFGEN ELFKQTDNPE GSWIRTVQNK LQKIMGFALP LFHARGVFQY NFGLMTYRKA IHTVVGRPIP VRQTLNPTQE QIEELHQTYM EELRKLFEEH KGKYGIPEHE TLVLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards