Diacylglycerol O-acyltransferase 2 (DGAT2)

About Diacylglycerol O-acyltransferase 2

Diacylglycerol O-acyltransferase 2 (DGAT2) is a protein from Homo sapiens identified by UniProt accession Q96PD7, 388 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.

Target properties

Protein name	Diacylglycerol O-acyltransferase 2
UniProt accession	Q96PD7
Gene	DGAT2
Organism	Homo sapiens
Length	388 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (130)

Diseases linked to this target (Open Targets).

lipoprotein measurement · score 0.45
high density lipoprotein cholesterol measurement · score 0.43
vitamin D measurement · score 0.41
bilirubin measurement · score 0.37
alcohol drinking · score 0.35
hemoglobin measurement · score 0.34
alcohol consumption measurement · score 0.33
hematocrit · score 0.31
serum albumin measurement · score 0.30
erythrocyte count · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96PD7-F1	alphafold	PREDICTED	87.99	—

Amino-acid sequence (388 residues)

MKTLIAAYSG VLRGERQAEA DRSQRSHGGP ALSREGSGRW GTGSSILSAL QDLFSVTWLN RSKVEKQLQV ISVLQWVLSF LVLGVACSAI LMYIFCTDCW LIAVLYFTWL VFDWNTPKKG GRRSQWVRNW AVWRYFRDYF PIQLVKTHNL LTTRNYIFGY HPHGIMGLGA FCNFSTEATE VSKKFPGIRP YLATLAGNFR MPVLREYLMS GGICPVSRDT IDYLLSKNGS GNAIIIVVGG AAESLSSMPG KNAVTLRNRK GFVKLALRHG ADLVPIYSFG ENEVYKQVIF EEGSWGRWVQ KKFQKYIGFA PCIFHGRGLF SSDTWGLVPY SKPITTVVGE PITIPKLEHP TQQDIDLYHT MYMEALVKLF DKHKTKFGLP ETEVLEVN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards