About Rho guanine nucleotide exchange factor 17
Rho guanine nucleotide exchange factor 17 (ARHGEF17) is a protein
from Homo sapiens identified by UniProt accession
Q96PE2, 2063 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 17 |
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| UniProt accession | Q96PE2 |
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| Gene | ARHGEF17 |
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| Organism | Homo sapiens |
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| Length | 2063 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PE2-F1 | alphafold | PREDICTED | 50.65 | — |
Amino-acid sequence (2063 residues)
MADGAPRPQL YRSVSFKLLE RWSGGPGLRE EDTDTPGLRR RASCRPTTAA RGQPSRRVSK LASGPLAAPA QPRPLRSLSP SVRQLSRRFD APRLDDGSAG TRDGGVLPAA AEEAAEGPAR GAWPSVTEMR KLFGGPGSRR PSADSESPGT PSPDGAAWEP PARESRQPPT PPPRTCFPLA GLRSARPLTG PETEGRLRRP QQQQERAQRP ADGLHSWHIF SQPQAGARAS CSSSSIAASY PVSRSRAASS SEEEEEGPPQ LPGAQSPAYH GGHSSGSDDD RDGEGGHRWG GRPGLRPGSS LLDQDCRPDS DGLNLSSMNS AGVSGSPEPP TSPRAPREEG LREWGSGSPP CVPGPQEGLR PMSDSVGGAF RVAKVSFPSY LASPAGSRGS SRYSSTETLK DDDLWSSRGS GGWGVYRSPS FGAGEGLLRS QARTRAKGPG GTSRALRDGG FEPEKSRQRK SLSNPDIASE TLTLLSFLRS DLSELRVRKP GGSSGDRGSN PLDGRDSPSA GGPVGQLEPI PIPAPASPGT RPTLKDLTAT LRRAKSFTCS EKPMARRLPR TSALKSSSSE LLLTGPGAEE DPLPLIVQDQ YVQEARQVFE KIQRMGAQQD DGSDAPPGSP DWAGDVTRGQ RSQEELSGPE SSLTDEGIGA DPEPPVAAFC GLGTTGMWRP LSSSSAQTNH HGPGTEDSLG GWALVSPETP PTPGALRRRR KVPPSGSGGS ELSNGEAGEA YRSLSDPIPQ RHRAATSEEP TGFSVDSNLL GSLSPKTGLP ATSAMDEGLT SGHSDWSVGS EESKGYQEVI QSIVQGPGTL GRVVDDRIAG KAPKKKSLSD PSRRGELAGP GFEGPGGEPI REVEPMLPPS SSEPILVEQR AEPEEPGATR SRAQSERALP EALPPPATAH RNFHLDPKLA DILSPRLIRR GSKKRPARSS HQELRRDEGS QDQTGSLSRA RPSSRHVRHA SVPATFMPIV VPEPPTSVGP PVAVPEPIGF PTRAHPTLQA PSLEDVTKQY MLNLHSGEVP APVPVDMPCL PLAAPPSAEA KPPEAARPAD EPTPASKCCS KPQVDMRKHV AMTLLDTEQS YVESLRTLMQ GYMQPLKQPE NSVLCDPSLV DEIFDQIPEL LEHHEQFLEQ VRHCMQTWHA QQKVGALLVQ SFSKDVLVNI YSAYIDNFLN AKDAVRVAKE ARPAFLKFLE QSMRENKEKQ ALSDLMIKPV QRIPRYELLV KDLLKHTPED HPDHPLLLEA QRNIKQVAER INKGVRSAEE AERHARVLQE IEAHIEGMED LQAPLRRFLR QEMVIEVKAI GGKKDRSLFL FTDLIVCTTL KRKSGSLRRS SMSLYTAASV IDTASKYKML WKLPLEDADI IKGASQATNR ENIQKAISRL DEDLTTLGQM SKLSESLGFP HQSLDDALRD LSAAMHRDLS EKQALCYALS FPPTKLELCA TRPEGTDSYI FEFPHPDARL GFEQAFDEAK RKLASSKSCL DPEFLKAIPI MKTRSGMQFS CAAPTLNSCP EPSPEVWVCN SDGYVGQVCL LSLRAEPDVE ACIAVCSARI LCIGAVPGLQ PRCHREPPPS LRSPPETAPE PAGPELDVEA AADEEAATLA EPGPQPCLHI SIAGSGLEMT PGLGEGDPRP ELVPFDSDSD DESSPSPSGT LQSQASRSTI SSSFGNEETP SSKEATAETT SSEEEQEPGF LPLSGSFGPG GPCGTSPMDG RALRRSSHGS FTRGSLEDLL SVDPEAYQSS VWLGTEDGCV HVYQSSDSIR DRRNSMKLQH AASVTCILYL NNQVFVSLAN GELVVYQREA GHFWDPQNFK SVTLGTQGSP ITKMVSVGGR LWCGCQNRVL VLSPDTLQLE HMFYVGQDSS RCVACMVDSS LGVWVTLKGS AHVCLYHPDT FEQLAEVDVT PPVHRMLAGS DAIIRQHKAA CLRITALLVC EELLWVGTSA GVVLTMPTSP GTVSCPRAPL SPTGLGQGHT GHVRFLAAVQ LPDGFNLLCP TPPPPPDTGP EKLPSLEHRD SPWHRGPAPA RPKMLVISGG DGYEDFRLSS GGGSSSETVG RDDSTNHLLL WRV
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