Defensin beta 118 (DEFB118)

About Defensin beta 118

Defensin beta 118 (DEFB118) is a protein from Homo sapiens identified by UniProt accession Q96PH6, 123 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Defensin beta 118
UniProt accession	Q96PH6
Gene	DEFB118
Organism	Homo sapiens
Length	123 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
lung adenocarcinoma · score 0.24
cutaneous melanoma · score 0.23
endometrial cancer · score 0.21
glioblastoma multiforme · score 0.20
ovarian cancer · score 0.18
squamous cell lung carcinoma · score 0.17
TPE interval measurement · score 0.16
head and neck squamous cell carcinoma · score 0.15
gastric adenocarcinoma · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96PH6-F1	alphafold	PREDICTED	62.89	—

Amino-acid sequence (123 residues)

MKLLLLALPM LVLLPQVIPA YSGEKKCWNR SGHCRKQCKD GEAVKDTCKN LRACCIPSNE DHRRVPATSP TPLSDSTPGI IDDILTVRFT TDYFEVSSKK DMVEESEAGR GTETSLPNVH HSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards