Small proline-rich protein 4 (SPRR4)

About Small proline-rich protein 4

Small proline-rich protein 4 (SPRR4) is a protein from Homo sapiens identified by UniProt accession Q96PI1, 79 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Small proline-rich protein 4
UniProt accession	Q96PI1
Gene	SPRR4
Organism	Homo sapiens
Length	79 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
granulocyte count · score 0.03
osteosarcoma · score 0.02
psoriasis · score 0.02
atopic eczema · score 0.01
rosacea · score 0.01
Dravet syndrome · score 0.01
cholesteryl ester measurement · score 0.00
acne · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96PI1-F1	alphafold	PREDICTED	67.36	—

Amino-acid sequence (79 residues)

MSSQQQQRQQ QQCPPQRAQQ QQVKQPCQPP PVKCQETCAP KTKDPCAPQV KKQCPPKGTI IPAQQKCPSA QQASKSKQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards