About Transcriptional-regulating factor 1
Transcriptional-regulating factor 1 (TRERF1) is a protein
from Homo sapiens identified by UniProt accession
Q96PN7, 1200 residues long.
MolForge cross-references it against 0 known binders and
171 disease associations.
Target properties
| Protein name | Transcriptional-regulating factor 1 |
|---|
| UniProt accession | Q96PN7 |
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| Gene | TRERF1 |
|---|
| Organism | Homo sapiens |
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| Length | 1200 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (171)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.41
- eosinophil percentage of leukocytes · score 0.39
- neutrophil count · score 0.37
- C-reactive protein measurement · score 0.34
- leukocyte count · score 0.32
- myeloid white cell count · score 0.30
- neutrophil percentage of granulocytes · score 0.30
- neurodegenerative disease · score 0.28
- eosinophil percentage of granulocytes · score 0.27
- monocyte percentage of leukocytes · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PN7-F1 | alphafold | PREDICTED | 49.19 | — |
Amino-acid sequence (1200 residues)
MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA SPISPHFPQD TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN LANSNMMWGA PAQAEPTDGY QYTYSQASEI RTQKLTSGVL HKLDSFTQVF ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA LRQLLSQKPM EPPAPAIPSR YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL AQVPVQGGQP LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS YHRDPHQYTP EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ QREDSQLKTY SSDRQAQAML SSHGDLGPPD TGMGDPASSD LTRVSSTLPH RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM HLPDGRAQPG SPESSGQPKG AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS PNLKQEEGEK VLPPQPQPPL PPPPPPPPPP QLPPEAESLT PMVMPVSVPV KLLPPKPSSQ GFTNSTVAAP SARDKPASSM SDDEMPVLEI PRKHQPSVPK AEEPLKTVQE KKKFRHRPEP LFIPPPPSYN PNPAASYSGA TLYQSQLRSP RVLGDHLLLD PTHELPPYTP PPMLSPVRQG SGLFSNVLIS GHGPGAHPQL PLTPLTPTPR VLLCRSNSID GSNVTVTPGP GEQTVDVEPR INIGLRFQAE IPELQDISAL AQDTHKATLV WKPWPELENH DLQQRVENLL NLCCSSALPG GGTNSEFALH SLFEAKGDVM VALEMLLLRK PVRLKCHPLA NYHYAGSDKW TSLERKLFNK ALATYSKDFI FVQKMVKSKT VAQCVEYYYT WKKIMRLGRK HRTRLAEIID DCVTSEEEEE LEEEEEEDPE EDRKSTKEEE SEVPKSPEPP PVPVLAPTEG PPLQALGQPS GSFICEMPNC GAVFSSRQAL NGHARIHGGT NQVTKARGAI PSGKQKPGGT QSGYCSVKSS PSHSTTSGET DPTTIFPCKE CGKVFFKIKS RNAHMKTHRQ QEEQQRQKAQ KAAFAAEMAA TIERTTGPVG APGLLPLDQL SLIKPIKDVD ILDDDVVQQL GGVMEEAEVV DTDLLLDDQD SVLLQGDAEL
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