About Guanylate-binding protein 5
Guanylate-binding protein 5 (GBP5) is a protein
from Homo sapiens identified by UniProt accession
Q96PP8, 586 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Guanylate-binding protein 5 |
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| UniProt accession | Q96PP8 |
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| Gene | GBP5 |
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| Organism | Homo sapiens |
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| Length | 586 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (156)
Diseases linked to this target (Open Targets).
- thyroid gland adenocarcinoma · score 0.18
- inflammatory bowel disease · score 0.16
- Neurodevelopmental disorder · score 0.12
- neoplasm · score 0.11
- triple-negative breast cancer · score 0.09
- oral squamous cell carcinoma · score 0.09
- glioblastoma multiforme · score 0.08
- small cell lung carcinoma · score 0.07
- non-small cell lung carcinoma · score 0.07
- cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PP8-F1 | alphafold | PREDICTED | 86.08 | — |
Amino-acid sequence (586 residues)
MALEIHMSDP MCLIENFNEQ LKVNQEALEI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KNKGFSVAST VQSHTKGIWI WCVPHPNWPN HTLVLLDTEG LGDVEKADNK NDIQIFALAL LLSSTFVYNT VNKIDQGAID LLHNVTELTD LLKARNSPDL DRVEDPADSA SFFPDLVWTL RDFCLGLEID GQLVTPDEYL ENSLRPKQGS DQRVQNFNLP RLCIQKFFPK KKCFIFDLPA HQKKLAQLET LPDDELEPEF VQQVTEFCSY IFSHSMTKTL PGGIMVNGSR LKNLVLTYVN AISSGDLPCI ENAVLALAQR ENSAAVQKAI AHYDQQMGQK VQLPMETLQE LLDLHRTSER EAIEVFMKNS FKDVDQSFQK ELETLLDAKQ NDICKRNLEA SSDYCSALLK DIFGPLEEAV KQGIYSKPGG HNLFIQKTEE LKAKYYREPR KGIQAEEVLQ KYLKSKESVS HAILQTDQAL TETEKKKKEA QVKAEAEKAE AQRLAAIQRQ NEQMMQERER LHQEQVRQME IAKQNWLAEQ QKMQEQQMQE QAAQLSTTFQ AQNRSLLSEL QHAQRTVNND DPCVLL
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