About Guanylate-binding protein 4
Guanylate-binding protein 4 (GBP4) is a protein
from Homo sapiens identified by UniProt accession
Q96PP9, 640 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Guanylate-binding protein 4 |
|---|
| UniProt accession | Q96PP9 |
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| Gene | GBP4 |
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| Organism | Homo sapiens |
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| Length | 640 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (90)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.20
- inflammatory bowel disease · score 0.14
- Immunodeficiency due to a late component of complements deficiency · score 0.10
- neoplasm · score 0.09
- infection · score 0.08
- infect · score 0.08
- non-small cell lung carcinoma · score 0.08
- cancer · score 0.08
- recurrent Neisseria infections due to factor D deficiency · score 0.07
- immunodeficiency 28 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PP9-F1 | alphafold | PREDICTED | 85.75 | — |
Amino-acid sequence (640 residues)
MGERTLHAAV PTPGYPESES IMMAPICLVE NQEEQLTVNS KALEILDKIS QPVVVVAIVG LYRTGKSYLM NRLAGKRNGF PLGSTVQSET KGIWMWCVPH LSKPNHTLVL LDTEGLGDVE KSNPKNDSWI FALAVLLSSS FVYNSVSTIN HQALEQLHYV TELAELIRAK SCPRPDEAED SSEFASFFPD FIWTVRDFTL ELKLDGNPIT EDEYLENALK LIPGKNPKIQ NSNMPRECIR HFFRKRKCFV FDRPTNDKQY LNHMDEVPEE NLERHFLMQS DNFCSYIFTH AKTKTLREGI IVTGKRLGTL VVTYVDAINS GAVPCLENAV TALAQLENPA AVQRAADHYS QQMAQQLRLP TDTLQELLDV HAACEREAIA VFMEHSFKDE NHEFQKKLVD TIEKKKGDFV LQNEEASAKY CQAELKRLSE HLTESILRGI FSVPGGHNLY LEEKKQVEWD YKLVPRKGVK ANEVLQNFLQ SQVVVEESIL QSDKALTAGE KAIAAERAMK EAAEKEQELL REKQKEQQQM MEAQERSFQE YMAQMEKKLE EERENLLREH ERLLKHKLKV QEEMLKEEFQ KKSEQLNKEI NQLKEKIEST KNEQLRLLKI LDMASNIMIV TLPGASKLLG VGTKYLGSRI
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