About Kelch-like protein 5
Kelch-like protein 5 (KLHL5) is a protein
from Homo sapiens identified by UniProt accession
Q96PQ7, 755 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Kelch-like protein 5 |
|---|
| UniProt accession | Q96PQ7 |
|---|
| Gene | KLHL5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 755 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (90)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- clear cell renal carcinoma · score 0.18
- myeloid white cell count · score 0.17
- mean corpuscular volume · score 0.15
- mean corpuscular hemoglobin concentration · score 0.11
- mean corpuscular hemoglobin · score 0.11
- mean reticulocyte volume · score 0.08
- sitting height measurement · score 0.07
- neoplasm · score 0.06
- red blood cell density measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PQ7-F1 | alphafold | PREDICTED | 77.60 | — |
Amino-acid sequence (755 residues)
MNVIYFPLHI FVVYSRAYTS LVLVGCTNLC AVLFARCLDD HLVSLRMSGS RKEFDVKQIL KIRWRWFGHQ ASSPNSTVDS QQGEFWNRGQ TGANGGRKFL DPCSLQLPLA SIGYRRSSQL DFQNSPSWPM ASTSEVPAFE FTAEDCGGAH WLDRPEVDDG TSEEENESDS SSCRTSNSSQ TLSSCHTMEP CTSDEFFQAL NHAEQTFKKM ENYLRHKQLC DVILVAGDRR IPAHRLVLSS VSDYFAAMFT NDVREARQEE IKMEGVEPNS LWSLIQYAYT GRLELKEDNI ECLLSTACLL QLSQVVEACC KFLMKQLHPS NCLGIRSFAD AQGCTDLHKV AHNYTMEHFM EVIRNQEFVL LPASEIAKLL ASDDMNIPNE ETILNALLTW VRHDLEQRRK DLSKLLAYIR LPLLAPQFLA DMENNVLFRD DIECQKLIME AMKYHLLPER RPMLQSPRTK PRKSTVGTLF AVGGMDSTKG ATSIEKYDLR TNMWTPVANM NGRRLQFGVA VLDDKLYVVG GRDGLKTLNT VECYNPKTKT WSVMPPMSTH RHGLGVAVLE GPMYAVGGHD GWSYLNTVER WDPQARQWNF VATMSTPRST VGVAVLSGKL YAVGGRDGSS CLKSVECFDP HTNKWTLCAQ MSKRRGGVGV TTWNGLLYAI GGHDAPASNL TSRLSDCVER YDPKTDMWTA VASMSISRDA VGVCLLGDKL YAVGGYDGQA YLNTVEAYDP QTNEWTQVAP LCLGRAGACV VTVKL
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