About E3 ubiquitin ligase RNF157
E3 ubiquitin ligase RNF157 (RNF157) is a protein
from Homo sapiens identified by UniProt accession
Q96PX1, 679 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | E3 ubiquitin ligase RNF157 |
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| UniProt accession | Q96PX1 |
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| Gene | RNF157 |
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| Organism | Homo sapiens |
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| Length | 679 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (107)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- BMI-adjusted waist-hip ratio · score 0.31
- waist-hip ratio · score 0.30
- monocyte percentage of leukocytes · score 0.25
- triglyceride measurement · score 0.17
- high density lipoprotein cholesterol measurement · score 0.16
- body height · score 0.09
- early-onset non-syndromic cataract · score 0.08
- lymphocyte count · score 0.07
- hereditary hyperferritinemia with congenital cataracts · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PX1-F1 | alphafold | PREDICTED | 59.89 | — |
Amino-acid sequence (679 residues)
MGALTSRQHA GVEEVDIPSN SVYRYPPKSG SYFASHFIMG GEKFDSTHPE GYLFGENSDL NFLGNRPVVF PYAAPPPQEP VKTLRSLVNI RKDTLRLVKC AEEVKSPGEE ASKAKVHYNV EFTFDTDARV AITIYYQATE EFQNGIASYI PKDNSLQSET VQYKRGVCQQ FCLPSHTVDP SEWAEEELGF DLDREVYPLV VHAVVDEGDE YFGHCHVLLG TFEKHTDGTF CVKPLKQKQV VDGVSYLLQE IYGIENKYNT QDSKVAEDEV SDNSAECVVC LSDVRDTLIL PCRHLCLCNT CADTLRYQAN NCPICRLPFR ALLQIRAMRK KLGPLSPTSF NPIISSQTSD SEEHPSSENI PPGYEVVSLL EALNGPLTPS PAVPPLHVLG DGHLSGMLPS YGSDGHLPPV RTISPLDRLS DSSSQGLKLK KSLSKSTSQN SSVLHEEEDE HSCSESETQL SQRPSVQHLG EECGVTPESE NLTLSSSGAI DQSSCTGTPL SSTISSPEGP ASSSLAQSVM SMASSQISTD TVSSMSGSYI APGTEEEGEA LSSPQPASRA PSEEGEGLPA ESPDSNFAGL PAGEQDAEGN DVIEEEDGSP TQEGQRTCAF LGMECDNNND FDIASVKALD NKLCSEVCLP GAWQADDNAV SRNAQRRRLS SSSLEDSETR PCVWGPLAV
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